Title of article
Completeness and unbiased estimation of mean vector in the multivariate group sequential case
Author/Authors
Liu، نويسنده , , Aiyi and Wu، نويسنده , , Chengqing and Yu، نويسنده , , Kai F. and Yuan، نويسنده , , Weishi، نويسنده ,
Issue Information
دوفصلنامه با شماره پیاپی سال 2007
Pages
12
From page
505
To page
516
Abstract
We consider estimation after a group sequential test about a multivariate normal mean, such as a χ 2 test or a sequential version of the Bonferroni procedure. We derive the density function of the sufficient statistics and show that the sample mean remains to be the maximum likelihood estimator but is no longer unbiased. We propose an alternative Rao–Blackwell type unbiased estimator. We show that the family of distributions of the sufficient statistic is not complete, and there exist infinitely many unbiased estimators of the mean vector and none has uniformly minimum variance. However, when restricted to truncation-adaptable statistics, completeness holds and the Rao–Blackwell estimator has uniformly minimum variance.
Keywords
Medical trials , Mean squared error , Restricted completeness , Truncation-adaptation , bias , interim analysis , Multiple endpoints , Minimum variance
Journal title
Journal of Multivariate Analysis
Serial Year
2007
Journal title
Journal of Multivariate Analysis
Record number
1558624
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