• Title of article

    Completeness and unbiased estimation of mean vector in the multivariate group sequential case

  • Author/Authors

    Liu، نويسنده , , Aiyi and Wu، نويسنده , , Chengqing and Yu، نويسنده , , Kai F. and Yuan، نويسنده , , Weishi، نويسنده ,

  • Issue Information
    دوفصلنامه با شماره پیاپی سال 2007
  • Pages
    12
  • From page
    505
  • To page
    516
  • Abstract
    We consider estimation after a group sequential test about a multivariate normal mean, such as a χ 2 test or a sequential version of the Bonferroni procedure. We derive the density function of the sufficient statistics and show that the sample mean remains to be the maximum likelihood estimator but is no longer unbiased. We propose an alternative Rao–Blackwell type unbiased estimator. We show that the family of distributions of the sufficient statistic is not complete, and there exist infinitely many unbiased estimators of the mean vector and none has uniformly minimum variance. However, when restricted to truncation-adaptable statistics, completeness holds and the Rao–Blackwell estimator has uniformly minimum variance.
  • Keywords
    Medical trials , Mean squared error , Restricted completeness , Truncation-adaptation , bias , interim analysis , Multiple endpoints , Minimum variance
  • Journal title
    Journal of Multivariate Analysis
  • Serial Year
    2007
  • Journal title
    Journal of Multivariate Analysis
  • Record number

    1558624