Title of article :
Stability properties and Hopf bifurcation of a delayed viral infection model with lytic immune response
Author/Authors :
Song، نويسنده , , Xinyu and Wang، نويسنده , , Shaoli and Dong، نويسنده , , Jing، نويسنده ,
Issue Information :
دوهفته نامه با شماره پیاپی سال 2011
Abstract :
A class of more general delayed viral infection model with lytic immune response is proposed based on some important biological meanings. The effect of time delay on stabilities of the equilibria is given. The sufficient criteria for local and global asymptotic stabilities of the viral free equilibrium and the local asymptotic stabilities of the no-immune response equilibrium are given. We also get the sufficient criteria for stability switch of the positive equilibrium. Numerical simulations are carried out to explain the mathematical conclusions.
Keywords :
Viral infection , Lytic immune response , Hopf bifurcation , center manifold
Journal title :
Journal of Mathematical Analysis and Applications
Journal title :
Journal of Mathematical Analysis and Applications