Author/Authors :
Uwe Starfinger، نويسنده , , C. and Chase، نويسنده , , J.G. and Hann، نويسنده , , C.E. and Shaw، نويسنده , , G.M. and Lambermont، نويسنده , , B. and Ghuysen، نويسنده , , A. and Kolh، نويسنده , , P. and Dauby، نويسنده , , P.C. and Desaive، نويسنده , , T.، نويسنده ,
Abstract :
A previously validated cardiovascular system (CVS) model and parameter identification method for cardiac and circulatory disease states are extended and further validated in a porcine model (N = 6) of induced endotoxic shock with hemofiltration. Errors for the identified model are within 10% when the model is re-simulated and compared to the clinical data. All identified parameter trends over time in the experiments match clinically expected changes both individually and over the cohort. This work represents a further clinical validation of these model-based cardiovascular diagnosis and therapy guidance methods for use with monitoring endotoxic disease states.
Keywords :
Parameter identification , Endotoxin , Integral method , Hemofiltration , Cardiovascular System , septic shock
