Author/Authors :
Onanuga، I.O. نويسنده Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin; P.M.B. 1515, Ilorin, Nigeria. , , Ibrahim، R.B. نويسنده Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin; P.M.B. 1515, Ilorin, Nigeria. , , Jaji-Sulaimon، R. نويسنده Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin; P.M.B. 1515, Ilorin, Nigeria. , , Tagoe، C.N.B. نويسنده Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin; P.M.B. 1515, Ilorin, Nigeria. , , Akinola، O.B. نويسنده Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin; P.M.B. 1515, Ilorin, Nigeria. ,
Abstract :
In this study we employed some histochemical techniques to evaluate the effect of ascorbic acid on azathioprine-induced alterations in the testis of adult Wistar rats. Male adult Wistar rats (n=30) with mean weight 210±2.65 g were assigned into four treatment (n=24) and control (n=6) groups. Animals were treated with 25 and 50 mg/kg azathioprine (AZA) alone (Grps II and IV) and in combination with 25 and 50 mg/kg ascorbic acid (Grps III and V) for 21 days while control animals received 1 ml distilled water. 24 h Post-treatment, animals were sacrificed, their testes were excised, weighed and fixed in Bouins’ fluid for histochemical studies of reticulin and collagen. The histochemical findings of testis sections indicated cyto-architectural distortions in the treated groups when compared to the control group. This findings show that ascorbic acid at doses administered did not ameliorate the damages caused by azathioprine.
