Immune response dynamics

The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We determine the analytic formula that describes the fine balance between Regulatory T cells and T cells at controlled and immune response equilibrium states. We demonstrate that cytokine dependent growth exhibits a quorum T cell population threshold that determines if immune responses develop on activation. We determine the analytic formulas of T cell proliferation thresholds that allow us to study the sensibility of the quorum growth thresholds controlling immune responses.