Title of article :
Synthesis of stereo-defined α-trifluoromethyl (Tfm)-malic units
Author/Authors :
Zucca، نويسنده , , Cristina and Bravo، نويسنده , , Pierfrancesco and Malpezzi، نويسنده , , Luciana and Volonterio، نويسنده , , Alessandro and Zanda، نويسنده , , Matteo، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
Aldol reactions of titanium enolates of N-acyl-1,3-oxazolidin-2-ones with ethyl trifluoropyruvate occurred with low to good stereoselectivity depending on the steric properties of the N-acyl group. Attempts to transform the resulting aldols into peptidomimetics incorporating stereo-defined α-trifluoromethyl (Tfm)-malic units are described.
Keywords :
Trifluoromethyl group , asymmetric synthesis , aldol reactions , oxazolidinones , Peptide isosteres
Journal title :
Journal of Fluorine Chemistry
Journal title :
Journal of Fluorine Chemistry
