Title of article
Synthesis of stereo-defined α-trifluoromethyl (Tfm)-malic units
Author/Authors
Zucca، نويسنده , , Cristina and Bravo، نويسنده , , Pierfrancesco and Malpezzi، نويسنده , , Luciana and Volonterio، نويسنده , , Alessandro and Zanda، نويسنده , , Matteo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
9
From page
215
To page
223
Abstract
Aldol reactions of titanium enolates of N-acyl-1,3-oxazolidin-2-ones with ethyl trifluoropyruvate occurred with low to good stereoselectivity depending on the steric properties of the N-acyl group. Attempts to transform the resulting aldols into peptidomimetics incorporating stereo-defined α-trifluoromethyl (Tfm)-malic units are described.
Keywords
Trifluoromethyl group , asymmetric synthesis , aldol reactions , oxazolidinones , Peptide isosteres
Journal title
Journal of Fluorine Chemistry
Serial Year
2002
Journal title
Journal of Fluorine Chemistry
Record number
1603523
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