Title of article :
1,4-Addition reaction of ethyl bromodifluoroacetate to Michael acceptors in the presence of copper powder: Improvement of the reaction using TMEDA as an additive
Author/Authors :
Sato، نويسنده , , Kazuyuki and Nakazato، نويسنده , , Sumika and Enko، نويسنده , , Hiroko and Tsujita، نويسنده , , Hiroaki and Fujita، نويسنده , , Katsumi and Yamamoto، نويسنده , , Takeya and Omote، نويسنده , , Masaaki and Ando، نويسنده , , Akira and Kumadaki، نويسنده , , Itsumaro، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
Reaction of ethyl bromodifluoroacetate with a variety of Michael acceptors was tremendously improved by the addition of TMEDA. Using this additive, 1,4-adducts were formed exclusively, and any 1,2-adducts or radical adducts were not obtained. THF or other low boiling solvents can be used as a solvent. This simplifies the work-up of the reaction effectively.
Keywords :
TMEDA , fluorine , Bromodifluoroacetate , Organocopper reagent , 1 , 4-addition
Journal title :
Journal of Fluorine Chemistry
Journal title :
Journal of Fluorine Chemistry
