Author/Authors :
Bonacorso، نويسنده , , Helio G and Lewandowski، نويسنده , , Hilario and Drekener، نويسنده , , Roberta de Souza Costa، نويسنده , , Michelle B and Pereira، نويسنده , , Claudio M.P and Wastowski، نويسنده , , Arci D and Peppe، نويسنده , , Clَvis and Martins، نويسنده , , Marcos A.P. and Zanatta، نويسنده , , Nilo، نويسنده ,
Abstract :
A new series of six 3-aryl-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1-picolinoylpyrazole hydrochlorides were synthesised in one-step in high yields by the reaction of β-methoxyvinyl trifluoromethyl ketones with 2-pyridinecarboxamidrazone in the presence of hydrochloric acid. The hydrochloride salts were easily converted to the respective new series of free trifluoromethylated 4,5-dihydro-1H-1-picolinoylpyrazoles using triethylamine in anhydrous diethyl ether. X-ray structure and 35Cl NMR data from the pyrazole hydrochlorides are reported.
Keywords :
enones , Hydrochlorides , pyrazoles , 35Cl NMR , Amidrazones
