Title of article
A novel reaction of allylic alcohols with hexafluoropropene-diethylamine adduct (PPDA) to form 2-fluoro-2-trifluoromethyl-4-alkenamide
Author/Authors
Ogu، نويسنده , , Ken-ichi and Akazome، نويسنده , , Motohiro and Ogura، نويسنده , , Katsuyuki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
12
From page
69
To page
80
Abstract
Treatment of allylic alcohols with hexafluoropropene-diethylamine adduct (PPDA) afforded N,N-diethyl-2-fluoro-2-trifluoromethyl-4-alkenamides which were formed by the Claisen rearrangement of intermediary 2-alkenyl-1-diethylamino-2,3,3,3-tetrafluoro-1-propenyl ethers. Although (E)-allylic alcohols gave two diastereomeric products in about 1:1 ratio, (Z)-allylic alcohols gave the corresponding product as a single diastereomer.
Keywords
2-Fluoro-2-trifluoromethyl-5-iodo-4-alkanolide , Hexafluoropropene-diethylamine adduct (PPDA) , Allylic alcohol , N , N-Diethyl-2-fluoro-2-trifluoromethyl-4-alkenamide , Claisen rearrangement , Iodolactonization
Journal title
Journal of Fluorine Chemistry
Serial Year
2003
Journal title
Journal of Fluorine Chemistry
Record number
1607842
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