Author/Authors :
Dolbier Jr.، نويسنده , , William R and Tian، نويسنده , , Jiang-Feng and Duan، نويسنده , , Jianxin and Li، نويسنده , , An-Rong and Ait-Mohand، نويسنده , , Samia and Bautista، نويسنده , , Olivia and Buathong، نويسنده , , Saiwan and Marshall Baker، نويسنده , , J and Crawford، نويسنده , , Jen and Anselme، نويسنده , , Pauline and Cai، نويسنده , , Xiao Hong and Modzelewska، نويسنده , , Aneta and Koroniak، نويسنده , , Henryk and Battiste، نويسنده , , Merle A and Chen، نويسنده , , Qing-Yun، نويسنده ,
Abstract :
TFDA is readily prepared from the reaction of fluorosulfonyldifluoroacetic acid with trimethylsilyl chloride, and it is a very effective and efficient source of difluorocarbene for use in addition reactions to alkenes of a broad scope of reactivities. Acid-sensitive substrates may require an additional purification step involving treatment of the distilled TFDA with sufficient Et3N to remove the acid impurity. Other trialkylsilyl fluorosulfonyldifluoroacetates can also be prepared, and they have been found to have reactivities similar to TFDA. The triethyl derivative, TEFDA is more convenient to prepare in a pure state and has similar reactivity to TFDA. Thus, it may prove to be a superior reagent.
