Title of article :
Synthesis of enantiomerically pure α-ethyl, α-vinyl and α-ethynyl 3,3,3-trifluoro alaninates
Author/Authors :
Crucianelli، نويسنده , , Marcello and Angelis، نويسنده , , Francesco De and Lazzaro، نويسنده , , Francesco and Malpezzi، نويسنده , , Luciana and Volonterio، نويسنده , , Alessandro and Zanda، نويسنده , , Matteo، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
We describe the first synthesis of enantiomerically pure (S)-α-vinyl and (S)-α-ethynyl 3,3,3-trifluoro alanine (TF-Ala) ethyl esters, starting from the in situ generated sulfinimine (S)-2 as key fluorinated building-block. (S)-α-Ethyl TF-Ala-OEt has been prepared as well by this route.
Keywords :
Trifluoromethyl , Sulfinimine , stereoselective synthesis , ?-Amino acids
Journal title :
Journal of Fluorine Chemistry
Journal title :
Journal of Fluorine Chemistry
