Title of article
Syntheses of new difluoromethylene benzoxazole and 1,2,4-oxadiazole derivatives, as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
Author/Authors
Medebielle، نويسنده , , Maurice and Ait-Mohand، نويسنده , , Samia and Burkhloder، نويسنده , , Conrad and Dolbier Jr.، نويسنده , , William R. and Laumond، نويسنده , , Géraldine and Aubertin، نويسنده , , Anne-Marie، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
8
From page
533
To page
540
Abstract
In an effort to prepare new fluorine-containing compounds, which are active against HIV, several chemical modifications of a series of benzoxazole and 1,2,4-oxadiazole-CF2CHOHAr derivatives were carried out. The products (9–30) which all have one or two CF2 groups were tested for activity against HIV-1; they were devoid of significant activity, one of them being cytotoxic.
Keywords
1 , 4-oxadiazole , 2 , Difluoromethyl heterocycles , Dehydroxylation , HIV , benzoxazole , fluorination , Oxidation
Journal title
Journal of Fluorine Chemistry
Serial Year
2005
Journal title
Journal of Fluorine Chemistry
Record number
1608872
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