A novel direct and one-pot Mannich synthesis of fluorinated β-aminobutanones with sulfamic acid as a green catalyst

A variety of fluorinated β-aminobutanones could be obtained in good to excellent yields at room temperature through the direct and three-component Mannich reactions of unmodified acetone with aldehydes and fluorinated anilines in one-pot procedure. Among the catalysts screened, sulfamic acid was tested to the best in aspect of outstanding stability, inexpensive cost, ready recovery and excellently catalytic activity. All the new compounds were confirmed by IR, 1H NMR, 13C NMR, 19F NMR and microanalysis.