Author/Authors :
Zhu، نويسنده , , Lingui and Li، نويسنده , , Ya-Ru Ni، نويسنده , , Chuanfa and Hu، نويسنده , , Jinbo and Beier، نويسنده , , Petr and Wang، نويسنده , , Ying and Surya Prakash، نويسنده , , G.K. and Olah، نويسنده , , George A.، نويسنده ,
Abstract :
We have successfully achieved nucleophilic (phenylsulfinyl)difluoromethylation of both enolizable and non-enolizable aldehydes and ketones by using difluoromethyl phenyl sulfone (1) as the fluoroalkylating agent. Although the chemical yields of the reactions are good to excellent, the observed diastereoselectivity is poor (dr = 1:1.04–2.03). The present synthetic methodology provides a convenient alternative for the preparation of α-(phenylsulfinyl)difluoromethylated carbinols that were previously synthesized via a two-step procedure.
