Title of article
New method of preparation of C2F5Li and its reactions with cyclic imines and lactims: Synthesis of α-pentafluoroethyl proline
Author/Authors
Shevchenko، نويسنده , , Nikolay E. and Nenajdenko، نويسنده , , Valentine G. and Rِschenthaler، نويسنده , , Gerd-Volker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
390
To page
396
Abstract
Addition of pentafluoroethyllithium to cyclic imines leads to pentafluoroethyl substituted pyrrolidines, piperidines and azepanes while reaction of cyclic lactims gives rise to 2-pentafluoroethyl imines. Oxidative cleavage of 2-furyl-2-pentafluoroethyl pyrrolidine has been found to be an effective method for the preparation of a racemic α-pentafluoroethyl proline.
Keywords
nucleophilic addition , Oxidative cleavage , Lewis acid , Pentafluoroethyl group , Cyclic imines , Azaheterocycles , ?-Pentafluoroethyl proline
Journal title
Journal of Fluorine Chemistry
Serial Year
2008
Journal title
Journal of Fluorine Chemistry
Record number
1610090
Link To Document