Title of article
Difluoromethylation of some C–H acids with chlorodifluoromethane under conditions of phase transfer catalysis (PTC)
Author/Authors
Nawrot، نويسنده , , Ewelina and Jo?czyk، نويسنده , , Andrzej، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
4
From page
466
To page
469
Abstract
Selected C–H acids react with difluorocarbene generated from chlorodifluoromethane with concentrated aqueous solution of sodium hydroxide, and a catalyst, benzyltriethylammonium chloride (TEBAC) in benzene or THF affording C-difluoromethyl substituted derivatives. This process is restricted to C–H acids of pKa ≅ 16.3–19.1. The observed facts are rationalized.
Keywords
difluorocarbene , Phase transfer catalysis , C–H acids , C-difluoromethylation
Journal title
Journal of Fluorine Chemistry
Serial Year
2009
Journal title
Journal of Fluorine Chemistry
Record number
1610489
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