Title of article
A new strategy for the synthesis of fluorinated 3,4-dihydropyrimidinones
Author/Authors
Fustero، نويسنده , , Santos and Catalلn، نويسنده , , Silvia and Aceٌa، نويسنده , , José Luis and del Pozo، نويسنده , , Carlos، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
6
From page
1145
To page
1150
Abstract
A new family of 3,4-dihydropyrimidinones (DHPMs) bearing fluorinated substituents at C6 have been prepared from gem-difluorinated nitriles, alkyl 3-butenoates and iso(thio)cyanates. This novel Biginelli-type process relies on the γ-addition of the ester-derived enolate to fluorinated nitriles. A tandem nucleophilic addition aza-Michael reaction sequence completes the synthetic process.
Keywords
Intramolecular aza-Michael reaction , multicomponent reactions , Fluorinated nitriles , Fluorinated dihydropyrimidinones
Journal title
Journal of Fluorine Chemistry
Serial Year
2009
Journal title
Journal of Fluorine Chemistry
Record number
1610716
Link To Document