Efficient synthesis of α-(fluoro/chloro/methoxy)disulfonylmethane derivatives as tunable substituted methyl synthons via a new C–S bond forming strategy

A new synthetic protocol for the preparation of α-fluoro(disulfonyl)methane and its chloro as well as methoxy analogues has been developed. Due to the synthetic utility of α-fluoro(bisphenylsulfonyl)methane (FBSM) as a versatile synthon in the preparation of various useful fluoromethylated organic molecules, search for an easy and economic for its preparation route has been essential. The C–S bond forming strategy is utilized in this new synthetic approach, which can be applied to a variety of substrates with high efficiency and selectivity.