A facile tandem reaction to access β-hydroxy-α,α-difluoroketone derivatives catalyzed by titanocene dichloride/magnesium

Tandem reactions of Barbier-type allylation, Brook rearrangement and fluoride-promoted aldol reaction were developed, which afforded a facile, “one-pot” process to β-hydroxy-α,α-difluoroketone derivatives with good to excellent yields.