Fluoro-Pummerer rearrangement and analogous reactions

Fluorine containing compounds hold huge promise for pharmaceuticals and agrochemicals due to their specific therapeutic potency or pesticide properties. Therefore, the development of selective and efficient methods for the introduction of fluorine or fluorinated groups into organic molecules is one of the most important tasks in organofluorine chemistry today. ive fluorinations of sulfur compounds like the fluoro-Pummerer rearrangement and analogous transformations such as oxidative desulfurization–fluorination reactions reveal mild, selective and efficient pathways toward mono-, di- or trifluorinated organic compounds. This article summarizes the synthetic approaches as well as the scope and limitations of fluoro-Pummerer rearrangements, oxidative desulfurization–fluorination, as well as the oxidative desulfurization–di- and trifluorination reactions. Application of these oxidative fluorination methods gives rise to various α-fluorinated sulfides, gem-difluorides and trifluoromethylated compounds.