Title of article :
Construction of chiral trifluoromethylated materials by combination of stereochemically predictable SN2′ reaction and Ireland-Claisen rearrangement
Author/Authors :
Ichikawa، نويسنده , , Tomoaki and Kawasaki-Takasuka، نويسنده , , Tomoko and Yamada، نويسنده , , Shigeyuki and Yamazaki، نويسنده , , Takashi and Kubota، نويسنده , , Toshio، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Abstract :
We have succeeded in establishment of a novel route for the construction of optically active CF3-containing carboxylic acids in a stereochemically predictable manner starting from easily available mandelic acid by convenient combination of the copper-mediated anti-SN2′ type substitution and Ireland-Claisen rearrangement.
Keywords :
Stereodivergent synthesis , Ireland-Claisen rearrangement , 2-Bromo-3 , SN2? reaction , 3-trifluoropropene , Trifluoromethyl group , 3
Journal title :
Journal of Fluorine Chemistry
Journal title :
Journal of Fluorine Chemistry
