Synthesis and characterization of fluorinated conjugates of albumin

A small fluorocarbon dendron that contains nine chemically identical fluorine atoms was covalently conjugated to albumin via a flexible linker. Two versions were made, which differ by 10% in the linker length. Both versions display split 19F signal and much shorter 19F longitudinal relaxation time than their small molecule counterparts. 10% difference in the flexible linker length has negligible impact on the 19F signal.