Title of article :
Synthesis of fluorinated pyrimidinones
Author/Authors :
Kosobokov، نويسنده , , Mikhail D. and Struchkova، نويسنده , , Marina I. and Arkhipov، نويسنده , , Dmitry E. and Korlyukov، نويسنده , , Alexander A. and Dilman، نويسنده , , Alexander D.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Abstract :
A method for the construction of fluorinated pyrimidinones based on the reaction of cyanodifluoromethyl-substituted amines with isocyanates is described. The use of ortho-iodophenylisocyanate in this reaction followed by copper catalyzed intramolecular amination affords fluorinated fused heterocycles – 4-fluoropyrimido[1,6-a]benzimidazol-1(2H)-ones.
Keywords :
Coupling reaction , Pyrimidinones , cyclization , Isocyanates , Heterocycles
Journal title :
Journal of Fluorine Chemistry
Journal title :
Journal of Fluorine Chemistry
