Synthesis and studies on photodynamic activity of new water-soluble azaphthalocyanines

Aza analogues of phthalocyanines (AzaPc’s) bearing four long chains with carboxy groups at the end and four “bulky” diethylamino groups on periphery were synthesised and characterised. Their sodium salts are very soluble in water. The first studies on photodynamic activity of this tetrapyrazinoporphyrazines (a type of AzaPc) are presented. The dye-sensitised photooxidation of 1,3-diphenylisobenzofurane via 1O2 was studied in pyridine. Their photodynamic activity in vitro was not detected due to the aggregation behaviour of these compounds in water.