Title of article
Semisynthetic Flavocytochromes Based on Cytochrome P450 2B4: Reductase and Oxygenase Activities
Author/Authors
Shumyantseva، نويسنده , , Victoria V. and Uvarov، نويسنده , , Valentine Yu. and Byakova، نويسنده , , Olga E. and Archakov، نويسنده , , Alexander I.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
133
To page
138
Abstract
A synthetic flavocytochrome with the reductase and oxygenase activities was obtained by covalent binding of riboflavin to cytochrome P450 2B4. The reactions catalyzed by the newly synthesized flavocytochromes were studied. Formation of carbon monoxide complex with the reduced form of hemoprotein led to 60–80% inhibition of oxygenase reactions, indicating the leading role of reduced heme iron in generating active oxygen species by flavocytochromes.
Journal title
Archives of Biochemistry and Biophysics
Serial Year
1998
Journal title
Archives of Biochemistry and Biophysics
Record number
1613067
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