Title of article
MP-Chitosan protects Caco-2 cells from toxic gliadin peptides
Author/Authors
Marco Silano، نويسنده , , Marco and Vincentini، نويسنده , , Olimpia and Muzzarelli، نويسنده , , Riccardo A.A. and Muzzarelli، نويسنده , , Corrado and De Vincenzi، نويسنده , , Massimo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
215
To page
219
Abstract
Caco-2 human intestinal cell line was exposed, both separately and simultaneously, to gliadin pepsin-tryptic digest and MP-chitosan. MP-Chitosan was able to depress the gliadin toxicity, and to lower caspase-3 activation and apoptosis, nitric oxide production, and lactate dehydrogenase release by the cells, whilst improving the cell viability. The interaction between MP-chitosan and mannose-receptor might account for some of these effects.
Keywords
Cell toxicity , gliadin , Celiac disease , Chitosan , apoptosis
Journal title
CARBOHYDRATE POLYMERS
Serial Year
2004
Journal title
CARBOHYDRATE POLYMERS
Record number
1613665
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