Title of article :
Genomic DNA Regions Whose Complementary Strands Are Prone to UV Light-Induced Crosslinking
Author/Authors :
Nejedl‎، نويسنده , , Karel and Kittner، نويسنده , , Radim and Kypr، نويسنده , , Jaroslav، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
9
From page :
216
To page :
224
Abstract :
We prepared an extensive set of DNA restriction fragments, irradiated them with UV light, and detected crosslinked complementary strands by electrophoresis in denaturing agarose gels. These experimental data were quantified by densitometry to determine tetranucleotide contributions to crosslinking. The tetranucleotide contributions were used to predict genomic maps of the crosslinking probability that permitted us to identify two strongly crosslinking genomic regions having 295 and 389 base pairs in length. The two sequences shared the (ATTTTATA).(TATAAAAT) octamer, which is a candidate for the hotspot of UV light-induced crosslinking between the complementary strands of DNA.
Journal title :
Archives of Biochemistry and Biophysics
Serial Year :
2001
Journal title :
Archives of Biochemistry and Biophysics
Record number :
1617893
Link To Document :
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