The application of an advanced visualized method in synthesis process optimization of carboxymethyl hydroxyethyl starch

Carboxymethyl hydroxyethyl starch with good transparency and high stability was prepared through two etherifications successively by adding 2-chloroethanol and chloroacetic acid as etherifying agents. A visualization method was used to optimize the proportion parameters and forecast the optimal process conditions. Carboxymethyl hydroxyethyl starch was prepared according to the optimal conditions, and the value of MS is about 0.3553 and DS is about 0.3412. It proves that visualization method is veracious and credible.