A synthetic macromolecule as MRI detectable drug carriers: Aminodextran-coated iron oxide nanoparticles

A new synthetic macromolecule, aminodextran-coated iron oxide nanoparticles, was synthesized as drug carrier detectable using magnetic resonance imaging (MRI) technique. The synthesis process starts with a 2-step reaction that attaches a high density of amino groups to a dextran backbone. These macromolecules were coated with magnetic iron oxide molecules by a chemical reaction that can carry several molecules such as drug and peptides. The aminodextran-coated iron oxide nanoparticles thus synthesized have been characterized by Fourier infrared (FT-IR) spectroscopy. Also, the morphology of this synthetic macromolecule was studied by scanning electron microscopy.