Author/Authors :
Saboktakin، Maryam نويسنده Nutrition Research Center, Department of Biochemistry, Nutrition and Diet Therapy, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. , , Mohammad Reza and Tabatabaee، نويسنده , , Roya M. and Maharramov، نويسنده , , Abel and Ramazanov، نويسنده , , Mohammad Ali، نويسنده ,
Abstract :
The main objective of this research is to design a new extended release multiparticulate delivery system by incorporation into nanoparticles made of chitosan-polymethacrylic acid copolymers. As the first part of a continued research on conversion of chitosan to useful biopolymer-based materials, by grafting polymethacrylic acid (PMAA), free radical graft copolymerization was carried out at 70 °C, with bis-acrylamide as a cross-linking agent and persulfate as an initiator. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids. Also, the paclitaxel as a model drug was entrapped in these nano-gels and in vitro release profiles were established separately in both enzyme-free SGF and SIF. The drug release was found to be faster in SIF.
Keywords :
Nanoparticles , Paclitaxel , Delivery system , Chitosan , Polymethacrylic acid
