Development of a chitosan–polyglutamate based injectable polyelectrolyte complex scaffold

In this study, the chitosan–polyglutamate hydrogel was developed as injectable polyelectrolyte complex (PEC) scaffold for bone regeneration. In practice, oppositely charged polyelectrolytes were mixed using a static injection mixer, the gelation time was less than 1 min. The resorbable PEC scaffold can be in situ-formed as a scaffold for osteoblast ingrowth. The canine alveolar defect model was used to evaluate the efficacy of PEC implants. The PEC scaffold was highly effective in enhancing bone regeneration. Moreover, the addition of CaSO4·2H2O (CSD) to PEC scaffold can further enhance the early stage healing of bone regeneration.