Author/Authors :
Lam، نويسنده , , Pik-Ling and Kok، نويسنده , , Stanton Hon-Lung and Ho، نويسنده , , Yiu-Wah and Wong، نويسنده , , Raymond Siu-Ming and Cheng، نويسنده , , Gregory Yin-Ming and Cheng، نويسنده , , Chor-Hing and Lam، نويسنده , , Kim-Hung and Gambari، نويسنده , , Roberto and Lee، نويسنده , , Kenneth Ka-Ho and Chui، نويسنده , , Chung Hin Chui، نويسنده ,
Abstract :
In this study, a novel green microencapsulation system was used to develop Phyllanthus urinaria (PU) extract containing microcapsules. Agar was used with gelatin as the wall matrix materials of microcapsules to prevent the use of toxic crosslinker formaldehyde. Microencapsulated PU extract was developed to improve the potential antifungal activities of PU water extracts. The active components and surface morphology of PU extract containing microcapsules were analyzed by liquid chromatography/mass spectrometry and scanning electron microscopy, respectively. The in vitro release study demonstrated that approximately 80% of drug was released after 120 h. PU loaded microcapsules were shown to have a stronger anti-Aspergillus niger activity than the free drug.
Keywords :
Agar , Aspergillus niger , gelatin , Phyllanthus urinaria , microcapsules
