Author/Authors :
Yang، نويسنده , , Yongmei and Liu، نويسنده , , Peifang and Chen، نويسنده , , Lixia and Liu، نويسنده , , Zhaojun and Zhang، نويسنده , , Huixue and Wang، نويسنده , , Jianjian and Sun، نويسنده , , Xuesong and Zhong، نويسنده , , Weiqi and Wang، نويسنده , , Na and Tian، نويسنده , , Ching-Kuo and Zhao، نويسنده , , Jingshun، نويسنده ,
Abstract :
An araban type polysaccharide (GBPw) was purified from the leaves of Ginkgo biloba. The present study aimed to investigate the protective effects of GBPw on focal ischemia/reperfusion (I/R) injury in rat brain. The results of this study demonstrated that GBPw had a positive effect on the rat brain when administered 7 days before focal cerebral I/R injury. This effect was evident with the improvements in neurological deficits, reduction in infarct volume, MDA content and the levels of pro-inflammatory cytokines (TNF-α and IL-1β), and elevation in the SOD and MPO activities and the levels of anti-inflammatory cytokine (IL-10). Thus, the beneficial effects of GBPw on cerebral I/R injury may result from the reduction of oxidative stress and the inhibition of NO production and inflammation induced by I/R. The neuroprotective effects of GBPw supplement may have potential implication in the future for prevention/protection against cerebral ischemic stroke.
Keywords :
polysaccharide , Ginkgo biloba L. , Purification , neuroprotection , Cerebral ischemia/reperfusional
