Title of article
Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin – the LUXEA (LUtein Xanthophyll Eye Accumulation) study
Author/Authors
Schalch، نويسنده , , Wolfgang and Cohn، نويسنده , , William and Barker، نويسنده , , Felix M. and Kِpcke، نويسنده , , Wolfgang and Mellerio، نويسنده , , John S. Bird، نويسنده , , Alan C. and Robson، نويسنده , , Anthony G. and Fitzke، نويسنده , , Fred F. and van Kuijk، نويسنده , , Frederik J.G.M، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
8
From page
128
To page
135
Abstract
The xanthophylls lutein (L) and zeaxanthin (Z) form the macular pigment with the highest density in the macula lutea. We investigated Macular Pigment Optical Density (MPOD) responses to supplementation with identically formulated (Actilease™) L or Z (OPTISHARP™) or L + Z over 6–12 months using doses of 10 or 20 mg/day. MPOD as well as blue light sensitivity in fovea and parafovea were measured monthly by heterochromatic flicker photometry. Average xanthophyll plasma concentrations, analysed monthly by HPLC, increased up to 27-fold. MPOD increased by 15% upon L or L + Z supplementation. Supplementation of Z alone produced similar pigment accumulation in fovea and parafovea, which confounded MPOD measurements. After correction for this, a 14% MPOD increase resulted for Z. Thus, during supplementation with xanthophylls, L is predominantly deposited in the fovea while Z deposition appears to cover a wider retinal area. This may be relevant to health and disease of the retina.
Keywords
Lutein , zeaxanthin , Supplementation , Heterochromatic flicker photometry , Fovea , macular pigment , Parafovea , OPTISHARP™ , carotenoids , AMD
Journal title
Archives of Biochemistry and Biophysics
Serial Year
2007
Journal title
Archives of Biochemistry and Biophysics
Record number
1628447
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