Title of article
Allosteric regulation of phenylalanine hydroxylase
Author/Authors
Fitzpatrick، نويسنده , , Paul F.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
8
From page
194
To page
201
Abstract
The liver enzyme phenylalanine hydroxylase is responsible for conversion of excess phenylalanine in the diet to tyrosine. Phenylalanine hydroxylase is activated by phenylalanine; this activation is inhibited by the physiological reducing substrate tetrahydrobiopterin. Phosphorylation of Ser16 lowers the concentration of phenylalanine for activation. This review discusses the present understanding of the molecular details of the allosteric regulation of the enzyme.
Keywords
phenylalanine hydroxylase , Allostery , regulation , tetrahydrobiopterin , phosphorylation
Journal title
Archives of Biochemistry and Biophysics
Serial Year
2012
Journal title
Archives of Biochemistry and Biophysics
Record number
1632714
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