Author/Authors :
Martins، نويسنده , , Marcos A.P. and Flores، نويسنده , , Alex F.C. and Bastos، نويسنده , , Giovani P. and Sinhorin، نويسنده , , Adilson and Bonacorso، نويسنده , , Helio G. and Zanatta، نويسنده , , Nilo، نويسنده ,
Abstract :
The one-pot synthesis of ten 5-carboxyisoxazoles from the cyclocondensation of β-alkoxyvinyl trichloromethyl ketones [CCl3C(O)C(R2)C(R1)OR, where R1, R2=H, Me and R=Me, Et] and 2-trichloroacetyl cyclohexanone with hydroxylamine is reported. This work shows that the trichloromethyl group attached to β-alkoxyvinyl trichloromethyl ketones (a heterocyclic CCC building block) is an excellent carboxyl group precursor.
