Title of article :
Solid phase synthesis of 3-(5′-carboxypentyl)-5-substituted tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives
Author/Authors :
Pérez، نويسنده , , Rolando and Reyes، نويسنده , , Osvaldo and Suarez، نويسنده , , Margarita and Garay، نويسنده , , Hilda E and Cruz، نويسنده , , Luis J and Rodr??guez، نويسنده , , Hortensia and Molero-Vilchez، نويسنده , , Mar??a D and Ochoa، نويسنده , , Carmen، نويسنده ,
Abstract :
The solid phase synthesis of 3-(5′-carboxypentyl)-5-substituted tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives 5 is described. 6-Amino-n-hexanoic acid was attached via its C-terminal to hydroxymethyl polystyrene using a ‘SASRIN’ linker. The bound amino acid was converted to the corresponding dithiocarbamate 3 followed by cyclization in the presence of formaldehyde and the corresponding free amino acids to afford 3-(5′-carboxypentyl)-5-substituted tetrahydro-2H-1,3,5-thiadiazin-2-thiones 4. The final products were cleaved from the resin and obtained in moderate yields.
