Novel carbohydrate scaffolds. Assembly of a uridine–mannose scaffold based on tunicamycin

A disaccharide scaffold based on tunicamycin was synthesized from d-uridine and l-mannose. The key step in disaccharide assembly was a β-mannosylation performed using Crich’s modification of the sulfoxide glycosylation method. The scaffold described contains two orthogonal derivatization sites and will be used in the search for novel biologically active compounds.