Title of article :
Efficient convergent synthesis of a trans-fused 6-6-6-6-membered tetracyclic ether ring system
Author/Authors :
Matsuo، نويسنده , , Goh and Hinou، نويسنده , , Hiroshi and Koshino، نويسنده , , Hiroyuki and Suenaga، نويسنده , , Toshiro and Nakata، نويسنده , , Tadashi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
A very efficient convergent strategy for the construction of the trans-fused 6-6-6-6-membered tetracyclic ether ring system was developed based on the acetylide-triflate coupling of two tetrahydropyrans, oxidation of the alkyne group to an α-diketone, double cyclization to 6,6,6,6-membered tetracyclic diacetal, and stereoselective reduction of the diacetal with Et3SiH–TMSOTf.
Keywords :
Alkynes , coupling reactions , acetals , tetrahydropyrans , polyethers , Reduction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
