Synthesis of marine sesterterpenoid dysidiolide

Dysidiolide, a novel sesterterpenoid isolated from the Caribbean sponge Dysidia etheria de Laubenfels, has been shown an inhibitor of protein phosphatase cdc25A. The authors established a stereocontrolled total synthesis of (±)-dysidiolide using an intramolecular Diels–Alder reaction as the key step.