Title of article
Regioselective synthesis of various prodrugs of ganciclovir
Author/Authors
Gao، نويسنده , , Hongwu and Mitra، نويسنده , , Ashim K، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
6
From page
1131
To page
1136
Abstract
High-yield regioselective syntheses of 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine mono-, di- and tri-substitution derivatives as potential prodrugs were accomplished via one or multisteps. Two amino acid esters of ganciclovir were synthesized as water-soluble prodrugs, which form protonated cations in pH 7.4 phosphate buffer.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636434
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