Title of article
Efficient synthesis of 1-heterocyclic-3-aminopyrrolidinones
Author/Authors
Bell، نويسنده , , Ian M and Beshore، نويسنده , , Douglas C and Gallicchio، نويسنده , , Steven C. R. Williams، نويسنده , , Theresa M، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
1141
To page
1145
Abstract
A novel two-step synthesis of optically active 3-aminopyrrolidinones is described. The route allows access to pyrrolidinones with heterocyclic functionality that is incompatible with known methodology, and affords the final products in good to excellent yield and high enantiomeric purity. The Mitsunobu cyclodehydration is shown to be an efficient method for the formation of a variety of γ-lactams.
Keywords
3-aminopyrrolidinones , Nitrogen Heterocycles , cyclization , Mitsunobu reaction
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636436
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