Author/Authors :
Hegde، نويسنده , , Vinod R and Puar، نويسنده , , Mohindar S and Dai، نويسنده , , Ping and Patel، نويسنده , , Mahesh and Gullo، نويسنده , , Vincent P and Das، نويسنده , , Pradip R and Bond، نويسنده , , Richard W and McPhail، نويسنده , , Andrew T، نويسنده ,
Abstract :
The organic extract of the fermentation broth of a Micromonospora microorganism was found to contain SCH 351448 (1), the monosodium salt of a macrocyclic dilactone containing two identical diacids. The structure and relative stereochemistry were established by single-crystal X-ray analysis. SCH 351448 is a novel ionophoric compound and is a weak activator of low density lipoprotein receptor (LDL-R) promoter with an IC50 of 25 μM.
