Title of article
A novel microbial metabolite, activator of low density lipoprotein receptor promoter
Author/Authors
Hegde، نويسنده , , Vinod R and Puar، نويسنده , , Mohindar S and Dai، نويسنده , , Ping and Patel، نويسنده , , Mahesh and Gullo، نويسنده , , Vincent P and Das، نويسنده , , Pradip R and Bond، نويسنده , , Richard W and McPhail، نويسنده , , Andrew T، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
1351
To page
1354
Abstract
The organic extract of the fermentation broth of a Micromonospora microorganism was found to contain SCH 351448 (1), the monosodium salt of a macrocyclic dilactone containing two identical diacids. The structure and relative stereochemistry were established by single-crystal X-ray analysis. SCH 351448 is a novel ionophoric compound and is a weak activator of low density lipoprotein receptor (LDL-R) promoter with an IC50 of 25 μM.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636482
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