Title of article
The synthesis of corticosteroid–carborane esters for the treatment of rheumatoid arthritis via boron neutron capture synovectomy
Author/Authors
Valliant، نويسنده , , John F and Schaffer، نويسنده , , Paul and Britten، نويسنده , , James F and Davison، نويسنده , , Alan and Jones، نويسنده , , Alun G and Yanch، نويسنده , , Jacquelyn C، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
1355
To page
1358
Abstract
Two corticosteroid–carborane esters were synthesized through the use of a BOP-Cl promoted esterification. The steroid–carborane conjugates are designed to selectively deliver boron to arthritic tissue for boron neutron capture synovectomy, a new therapeutic approach for rheumatoid arthritis.
Keywords
boron neutron capture synovectomy , Carborane , Corticosteroids , arthritis , BOP-Cl
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636483
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