Title of article
Reaction mechanism of the macrophomate synthase: experimental evidence on intermediacy of a bicyclic compound
Author/Authors
Watanabe، نويسنده , , Kenji and Mie، نويسنده , , Takashi and Ichihara، نويسنده , , Akitami and Oikawa، نويسنده , , Hideaki and Honma، نويسنده , , Mamoru، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
1443
To page
1446
Abstract
In the reaction of methyl coumalate 4 and oxalacetate with the macrophomate synthase, an aberrant product 5 was formed instead of the expected benzoate 6. The structure of 5 strongly indicates intermediacy of a bicyclic compound 10 in the extraordinary five-step transformation catalyzed by the macrophomate synthase.
Keywords
enzymes , Enzyme reaction , Mechanisms
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636502
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