Author/Authors :
Matsumoto، نويسنده , , Sandra S and Sidford، نويسنده , , Mathew H and Holden، نويسنده , , Joseph A and Barrows، نويسنده , , Louis R and Copp *، نويسنده , , Brent R، نويسنده ,
Abstract :
The cytotoxic marine alkaloid ascididemin has been shown to be a thiol-dependent DNA cleaving agent. Previous mechanisms of action studies have concluded that DNA and/or the DNA processing enzyme topoisomerase II were the cellular targets for the alkaloid—this is the first direct evidence that a pyridoacridone alkaloid can cause DNA cleavage under physiological conditions.
