Title of article :
Synthesis of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide gyrase B inhibitors
Author/Authors :
Peixoto، نويسنده , , Christophe and Laurin، نويسنده , , Patrick and Klich، نويسنده , , Michel and Dupuis-Hamelin، نويسنده , , Claudine and Mauvais، نويسنده , , Pascale and Lassaigne، نويسنده , , Patrice and Bonnefoy، نويسنده , , Alain and Musicki، نويسنده , , Branislav، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
The design, synthesis and in vitro biological evaluation of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide analogues of coumarin inhibitors of gyrase B are described. Compared to coumarin derivatives, compounds of the 1,2-benzooxathiin 2,2-dioxide series display improved inhibitory potency in negative supercoiling of relaxed DNA gyrase.
Keywords :
Hydrogen bonding , Structure–activity , antibiotics , Glycosidation
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
