Author/Authors :
Schoop، نويسنده , , Andreas and Greiving، نويسنده , , Helmut and Gِhrt، نويسنده , , Axel، نويسنده ,
Abstract :
A new analogue of rocaglamide 1 has been synthesised. The tricyclic core structure that is lacking the C-8b hydroxy group was generated in an oxidative addition of 1,3-cyclohexanedione to a cyclopentene moiety forming a tricyclic dihydrofuran system. Further transformation gave analogue 12 with the desired configuration. Although this C-8b deoxy derivative exhibits no insecticidal activity, it provides important information in understanding the structure–activity relationship.
