Author/Authors :
Benjamin Mugrage، نويسنده , , Ben and Diefenbacher، نويسنده , , Clive and Somers، نويسنده , , Joe and Parker، نويسنده , , David J and Parker، نويسنده , , Tonia، نويسنده ,
Abstract :
The phosphonic acid analog of the NSAID Diclofenac was efficiently synthesized via an Arbuzov reaction between 2-(2,6-dichloroanilino)benzyl alcohol and trimethyl phosphite followed by TMSBr promoted dealkylation. Seven related phosphonic acids were synthesized using the same novel acid-catalyzed Arbuzov reaction as the key step.
