Title of article
Phosphonic acid analogs of diclofenac: an Arbuzov reaction of trimethylphosphite with an ortho-quinonoid intermediate
Author/Authors
Benjamin Mugrage، نويسنده , , Ben and Diefenbacher، نويسنده , , Clive and Somers، نويسنده , , Joe and Parker، نويسنده , , David J and Parker، نويسنده , , Tonia، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
2047
To page
2050
Abstract
The phosphonic acid analog of the NSAID Diclofenac was efficiently synthesized via an Arbuzov reaction between 2-(2,6-dichloroanilino)benzyl alcohol and trimethyl phosphite followed by TMSBr promoted dealkylation. Seven related phosphonic acids were synthesized using the same novel acid-catalyzed Arbuzov reaction as the key step.
Keywords
quinonoid compounds , phosphonic acids and derivatives , Arbuzov reactions
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636636
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