Title of article
Use of the N-tosyl-activated aziridine 1,2-dideoxy-1,2-iminomannitol as a synthon for 1-deoxymannojirimycin analogues
Author/Authors
Joly، نويسنده , , Gert J and Peeters، نويسنده , , Koen and Mao، نويسنده , , Hua and Brossette، نويسنده , , Thierry and Hoornaert، نويسنده , , Georges J and Compernolle، نويسنده , , Frans، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
2223
To page
2226
Abstract
1-Amino-1-deoxy-d-glucitol was converted into the selectively protected title compound 4, an N-tosyl-activated aziridine that readily underwent ring opening with various nucleophiles. Further deprotection of the 5,6-diol moiety followed by ring closure under Mitsunobu conditions afforded the corresponding 6-substituted analogues of 1-deoxymannojirimycin.
Keywords
Aziridines , piperidines , Mitsunobu reactions , carbohydrates
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636690
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